The response of human sensory neurons to capsaicin (200nM) is recorded using calcium imaging technology. The increase in intracellular calcium concentration resulting from the opening of TRPV1 channels, is visualized using the calcium indicator Fluo 8
Phase-X is the proprietary technology developed by AnaBios which enables the investigation of human drug responses in the pre-clinical stage of drug discovery. These research methods are at the core of AnaBios preclinical drug discovery.
In the past, access to human cells and tissues for research has relied, almost invariably, on samples collected employing inconsistent protocols, variable postmortem intervals and a lack of adequate reagents for ensuring sample viability. As a result of ischemic damage, most available samples were of poor quality and provided inconsistent results. It has also been difficult, if not impossible, to use human tissue samples for functional biochemical and physiological testing of drug effects.